History: Array Vision Engineering (AVE) was incorporated by Dr. Porumbescu in 1990 in order to buy ITT’s Tube & Sensor Labs in Ft. Wayne, Indiana: the intent was to use those facilities to develop wedge-and-strip position-sensitive photo-detectors, however, ITT backed out, and AVE developed an electro-optical joystick for power wheelchairs instead. When the founder’s son was diagnosed with type 1 diabetes in 1992, he shifted focus to improving blood glucose control but was unable to go beyond the proof of concept phase because of health issues of his own after recovering, the company name was changed to Mangesius (AKA Proactive Metabolics) and its activity was limited to selling legacy diabetes management software. Proactive Metabolics Co.’s initial market offerings allow the use of systems biology tools for the proactive management of the effects of food, medication, physical activity, and stress on the blood glucose concentration – an important issue in weight management, and the diabetic patient’s most important concern.

     Now retired from teaching, the founder is intensely interested to bring his patented blood glucose control technology to the world, and we believe that ours is the only system capable of generating individual-specific contemporaneous predictions and thus help patients mitigate the health risks associated with improper blood glucose levels. We won funded research grants from NIH (NIDDK), DoD (BMDO), Sandia, and Lifescan Corp., and we sponsored research projects at Duke University, University of Florida, Bucharest Polytechnic Institute and Sandia National Laboratories.

     In a nutshell, our mission is to use the Proactive Metabolics’ mathematical modeling methods as the platform for real time metabolic control, which combines biomarker sensors, ubiquitous WiFi, and personal, walking around user experience into offerings via the Internet of Things and the mobile Health cloud. (This work is not limited to blood glucose dynamics.)


Abstract of the talk/presentation at the JDF/NASA Non/Minimally Invasive Measurement of Biological Analytes Technology Workshop (April 8-9, 1998 – Washington D.C.) 

Integrated Optoelectronic Sensor Suitable for Multivariate Analysis of Complex Spectra 
Aureliu M. Porumbescu 
Array Vision Engineering Co.



A food database accounting not for the one dimensional, simplistic caloric or carbohydrate values of food, but also for the other two key factors: the individual and the time.


Expert software for prescribing the insulin regimen in diabetes. The TAG_Angel Software uses the duality between input dynamics and the structure of the user’s metabolic system to predict how food or activity will affect blood glucose (and insulin, weight gain/loss, or energy) over time.