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The most common reasons for prolactin secretion include: The release of a new hormone by the anterior pituitary (which helps in the production of the pituitary hormones) The release of prolactin by an endocrine organ, such as by the ovaries, uterus, adrenals or thyroid. The release of prolactin by an immunologically-active molecule called prolactin receptor substrate (PRSS) in the anterior pituitary, . The production of prolactin by the adrenal gland (see also Adrenal Glands and Hormones). The release of prolactin by the pituitary gland (receptors can act as both hormones).